DSI Affiliated Faculty, Juan Perilla uncovers the nucleotide entry mechanism, a key step in its replication, using HIV-1 viral capsid simulations on XSEDE-allocated Stampede2, Bridges, Darwin systems. This computational biophysics research, challenges the prevailing view of the viral capsid. The Darwin supercomputer, a new XSEDE-allocated resource was launched by DSI on December 2020. Dr. Perilla, received an immense amount of help from UD’s XSEDE Campus Champion, Anita Schwartz, a member of the DSI Infrastructure Working Group that maintains the DARWIN Compute and Storage System.