Epigenetic Mechanisms of Cellular Heterogeneity in Gene Expression
Senior Investigator, Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health
Time: September 23, 2019 @ 3:30 PM
Location: Delaware Biotechnology Institute, 102
Recent studies have revealed a substantial variation in gene expression across different single cells, even within a homogeneous population of cells. In order to understand the underlying mechanisms of the cellular variation, we have developed single-cell techniques, including scDNase-seq and scMNase-seq, to analyze the epigenomic profiles at a single-cell level. Application of these techniques to various cell types revealed unexpected rules of chromatin organization and provided insights into the epigenetic basis of cellular heterogeneity in gene expression.